The story is fairly simple. An attractive intelligent but completely ruthless young woman, who is completely devoid of empathy, associates with someone of talent in a particular field. She psychologically becomes that person, steals and adapts their work and becomes famous for it. She leaves in her wake a trail of broken lives, suicide, and murder.
It is both fascinating and horrifying at the same time, perhaps even noirish with its femme fatale protagonist. Tezuka populates this graphic novel with a bunch of individual and interesting characters many of whom, even knowing what she is like, are unable to resist her, though one does. Toshiko Tomura, the protagonist herself, is either an enigma or an utterly self-centred psychopath depending upon your own interpretation of what Tezuka is attempting to portray. Even the ending has an ambiguity to it. It's difficult to discuss actual details without spoiling it so I won't.
One thing that is astonishing is that a work of such maturity and skill was published in Japan at the same time as American comics (Undergrounds excepted) were dominated by superhero comics aimed at children and teenagers. It's taken 30-40 years for these mature stories by Tezuka to appear in the West which is just a shame. Better late than never, but it's interesting to speculate what might have happened if western creators had been aware of them then and the impact it could have had.